Analysis of Hierarchical Organization in Gene Expression Networks Reveals Underlying Principles of Collective Tumor Cell Dissemination and Metastatic Aggressiveness of Inflammatory Breast Cancer

Clusters of circulating tumor cells (CTCs), despite being rare, may account for more than 90% of metastases.Cells in these clusters do not undergo a complete epithelial-to-mesenchymal transition (EMT), but retain some epithelial traits as compared to individually disseminating tumor cells.Determinants of single cell dissemination versus collective

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Features of histological structure and differential diagnostics of the diffuse-type giant cell tumor and its malignant form.

Background.Tenosynovial giant cell tumor of diffuse type is one of the most widespread tumor of joints, causing destruction of the soft tissues and bone articular surfaces.Objective.The purpose of the study was to formulate approaches to histological differential diagnostics between diffuse-type giant cell tumor and its malignant forms.Methods.Tiss

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Revisiting the binding designation between source and target domains in the creation of Javanese food names metaphors

This study aims to investigate metaphorical representation in Javanese food names in terms of linguistic MACASURE forms, metaphorical element distribution, similarity basis, source domains, and sociocultural factors underlying their existence.This study employed a qualitative approach by positioning researchers for collecting and generating data th

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Forging of nicotine for the effective management of diabetic wounds: A hybrid of scaffold hopping and molecular dynamics simulation approaches

Diabetic wound (DW) is a huge threat to the health care community and is always challenging to treat.The main biochemical culprits in DW recalcitrance are elevated inflammatory mediators, proteases, cell proliferation and migration suppressors, anti-angiogenic factors, and bacterial Breakfast infections.In this scenario, using a scaffold to target

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